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KMID : 0606920130210050323
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Biomolecules & Therapeutics
2013 Volume.21 No. 5 p.323 ~ p.331
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Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy
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Sheen Yhun Yhong
Kim Min-Jin
Park Sang-A
Park So-Yeon
Nam Jeong-Seok
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Abstract
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TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
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KEYWORD
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Transforming growth factor-β (TGF-β), EW-7197, ALK5, Breast cancer, Metastasis
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